Spectroscopic test of Bose-Einstein statistics for photons

Using Bose-Einstein-statistics-forbidden two-photon excitation in atomic barium, we have limited the rate of statistics-violating transitions, as a fraction $\nu$ of an equivalent statistics-allowed transition rate, to $\nu<4.0\times10^{-11}$ at the 90% confidence level. This is an improvement of more than three orders of magnitude over the best previous result. Additionally, hyperfine-interaction enabling of the forbidden transition has been observed, to our knowledge, for the first time

Significant association of a M129V independent polymorphism in the 5\prime UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study

Background: A single nucleotide polymorphism (SNP) in the coding region of the prion protein gene (PRNP) at codon 129 has been repeatedly shown to be an associated factor to sporadic Creutzfeldt-Jakob disease (sCJD), but additional major predisposing DNA variants for sCJD are still unknown. Several previous studies focused on the characterisation of polymorphisms in PRNP and the prion-like doppel gene (PRND), generating contradictory results on relatively small sample sets. Thus, extensive studies are required for validation of the polymorphisms in PRNP and PRND.Methods: We evaluated a set of nine SNPs of PRNP and one SNP of PRND in 593 German sCJD patients and 748 German healthy controls. Genotyping was performed using MALDI-TOF mass spectrometry.Results: In addition to PRNP 129, we detected a significant association between sCJD and allele frequencies of six further PRNP SNPs. No significant association of PRND T174M with sCJD was shown. We observed strong linkage disequilibrium within eight adjacent PRNP SNPs, including PRNP 129. However, the association of sCJD with PRNP 1368 and PRNP 34296 appeared to be independent on the genotype of PRNP 129. We additionally identified the most common haplotypes of PRNP to be over-represented or under-represented in our cohort of patients with sCJD.Conclusion: Our study evaluated previous findings of the association of SNPs in the PRNP and PRND genes in the largest cohorts for association study in sCJD to date, and extends previous findings by defining for the first time the haplotypes associated with sCJD in a large population of the German CJD surveillance study

On the interaction of a single-photon wave packet with an excited atom

The interaction of a single-photon wave packet with an initially excited two-level atom in free space is studied in semiclassical and quantum approaches. It is shown that the final state of the field does not contain doubly occupied modes. The process of the atom's transition to the ground state may be accelerated, decelerated or even reversed by the incoming photon, depending on parameters. The spectrum of emitted radiation is close to the sum of the spectrum of the incoming single-photon wave packet and the natural line shape, with small and complicated deviations.Comment: 17 pages, 5 figure

Lung cancer in lifetime nonsmoking men – results of a case-control study in Germany

Epidemiological studies of lung cancer among nonsmoking men are few. This case–control study was conducted among lifetime nonsmoking men between 1990 and 1996 in Germany to examine lung cancer risk in relation to occupation, environmental tobacco smoke, residential radon, family history of cancer and previous lung disease. A total of 58 male cases with confirmed primary lung cancer and 803 male population controls who had never smoked more than 400 cigarettes in their lifetime were personally interviewed by a standardized questionnaire. In addition, 1-year radon measurements in the living and bedroom of the subjects' last dwelling were carried out. Unconditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Having ever worked in a job with known lung carcinogens was associated with a two-fold significantly increased lung cancer risk (OR = 2.2; Cl = 1.0–5.0), adjusted for age and region. The linear trend test for lung-cancer risk associated with radon exposure was close to statistical significance, demonstrating an excess relative risk for an increase in exposure of 100 Bq m−3 of 0.43 (P = 0.052). Nonsignificantly elevated effects of exposure to environmental tobacco smoke in public transportation and in social settings were observed. No associations with a family history of cancer or previous lung diseases were found. Our results indicate that occupational carcinogens and indoor radon may play a role in some lung cancers in nonsmoking men. © 2001 Cancer Research Campaign http://www.bjcancer.co

Turbulent Flow-Driven Molecular Cloud Formation: A Solution to the Post-T Tauri Problem?

We suggest that molecular clouds can be formed on short time scales by compressions from large scale streams in the interstellar medium (ISM). In particular, we argue that the Taurus-Auriga complex, with filaments of 10-20 pc $\times$ 2-5 pc, most have been formed by H I flows in $\lesssim 3$Myr, explaining the absence of post-T Tauri stars in the region with ages $\gtrsim 3$ Myr. Observations in the 21 cm line of the H I `halos' around the Taurus molecular gas show many features (broad asymmetric profiles, velocity shifts of H I relative to $^{12}$CO) predicted by our MHD numerical simulations, in which large-scale H I streams collide to produce dense filamentary structures. This rapid evolution is possible because the H I flows producing and disrupting the cloud have much higher velocities (5-10 kms) than present in the molecular gas resulting from the colliding flows. The simulations suggest that such flows can occur from the global ISM turbulence without requiring a single triggering event such as a SN explosion.Comment: 26 pages, 12 ps figures. Apj accepte

The Chromo-Dielectric Soliton Model: Quark Self Energy and Hadron Bags

The chromo-dielectric soliton model (CDM) is Lorentz- and chirally-invariant. It has been demonstrated to exhibit dynamical chiral symmetry breaking and spatial confinement in the locally uniform approximation. We here study the full nonlocal quark self energy in a color-dielectric medium modeled by a two parameter Fermi function. Here color confinement is manifest. The self energy thus obtained is used to calculate quark wave functions in the medium which, in turn, are used to calculate the nucleon and pion masses in the one gluon exchange approximation. The nucleon mass is fixed to its empirical value using scaling arguments; the pion mass (for massless current quarks) turns out to be small but non-zero, depending on the model parameters.Comment: 24 pages, figures available from the author

Associations between mortality and air pollution in central Europe.

Increased mortality has been observed in association with elevated concentrations of air pollutants in European cities and in the United States. We reassessed the effects of particulate matter in Central Europe. Mortality and air pollution data were obtained for a highly polluted region of the Czech Republic and a rural region in Germany. Poisson regression analyses were conducted considering trend, season, meteorology, and influenza epidemics as confounders in both a parametric and a nonparametric approach. The Czech Republic had a 3.8% increase in mortality [95% confidence interval (CI), 0.8-6.9%] in association with 100 microg/m(3) total suspended particles (TSP) (lagged 2 days) for the time period 1982-1994. During the last 2 years of study, 68% of the TSP consisted of particulate matter [less than/equal to] 10 microm in aerodynamic diameter (PM(10)). An increase of 100 microg/m(3) TSP (lagged 1 day) was associated with a 9.5% increase in mortality (CI, 1.2-18.5%) and 100 microg/m(3) PM(10 )(lagged 1 day) showed a 9.8% increase in mortality (CI, 0.7-19.7%). We found no evidence for an association between mortality and particulate matter in the rural area in Germany at the Czech border. Data from the coal basin in the Czech Republic suggested an increase in mortality associated with the concentration of particulate matter in a highly polluted setting in Central Europe that is consistent with the associations observed in other western European cities and in the United States